Discover the Top Medications for Restless Legs: Expert Recommendations and Reviews

Restless legs syndrome can be a frustrating condition to deal with. If you’re searching for the best medication to alleviate your symptoms, read on for some helpful tips and recommendations.

Common Symptoms of Restless Legs Syndrome


Restless legs syndrome (RLS) is a neurological disorder that causes an irresistible urge to move the legs. This is often accompanied by uncomfortable sensations in the legs, such as tingling, itching, or burning. Symptoms typically worsen at night or when sitting for extended periods.


The following are common symptoms of RLS:

  • An irresistible urge to move the legs
  • Tingling, itching, or burning sensations in the legs
  • Leg discomfort that worsens at night or when sitting for long periods
  • Difficulty falling asleep or staying asleep due to leg discomfort
  • Periodic limb movements during sleep (PLMS)

Periodic Limb Movements During Sleep (PLMS)

PLMS is a common symptom of RLS and involves repetitive jerking movements of the legs during sleep. These movements can be disruptive to sleep and may cause daytime fatigue.

Risk Factors

The following factors may increase your risk of developing RLS:

  • Family history of RLS
  • Pregnancy
  • Chronic diseases such as kidney failure, diabetes, or Parkinson’s disease
  • Nerve damage caused by injury or surgery
  • Certain medications such as antipsychotics and antidepressants

Diagnosis and Treatment of Restless Legs Syndrome


To diagnose RLS, your doctor will perform a physical exam and ask about your symptoms. They may also order blood tests to rule out other conditions that may cause similar symptoms. In some cases, a sleep study may be recommended to evaluate for PLMS.


Treatment for RLS focuses on relieving symptoms and improving sleep quality. The following treatments may be recommended:

  • Medications to reduce leg discomfort and improve sleep
  • Lifestyle changes such as regular exercise and avoiding caffeine and alcohol
  • Alternative therapies such as massage or acupuncture

Types of Medications Used to Treat Restless Legs Syndrome

Dopamine Agonists

Dopamine agonists are the most commonly used medications for treating RLS. These drugs work by increasing dopamine levels in the brain, which can reduce leg discomfort and improve sleep quality. Some examples of dopamine agonists include pramipexole (Mirapex) and ropinirole (Requip).

Iron Supplements

Iron deficiency has been linked to RLS in some cases. Iron supplements may be recommended if blood tests show low iron levels.


Opioids may be prescribed for severe cases of RLS that do not respond to other treatments. These drugs can be effective at reducing leg discomfort but carry a risk of addiction and other side effects.

Potential Side Effects of Medication for Restless Legs Syndrome

While medication can be effective at treating RLS, it can also cause side effects. Common side effects of medication for RLS include nausea, dizziness, and fatigue. Dopamine agonists may also increase the risk of impulse control disorders such as compulsive gambling or shopping.

Using Lifestyle Changes and Alternative Therapies to Manage Restless Legs Syndrome

Lifestyle Changes

The following lifestyle changes may be helpful in managing RLS:

  • Regular exercise
  • Avoiding caffeine and alcohol
  • Establishing a regular sleep routine

Alternative Therapies

The following alternative therapies may be helpful in managing RLS:

  • Massage therapy
  • Acupuncture
  • Meditation or yoga

It is important to note that while these therapies may be beneficial for some people, they have not been scientifically proven to treat RLS. It is important to discuss any alternative therapies with your doctor before trying them.

In conclusion, the best medication for restless legs varies from person to person and should be determined by a medical professional after considering individual factors such as age, health status, and other medications being taken.


What is the best prescription drug for restless leg syndrome?

Neupro and Mirapex are medications that have been approved by the Food and Drug Administration to treat moderate to severe RLS. These drugs typically have mild short-term side effects such as nausea, dizziness, and fatigue.

What muscle relaxer is good for restless legs?

Muscle relaxants are typically prescribed for muscle spasms and back pain, but they can also be used to treat RLS. In some cases, low doses of muscle relaxants may be combined with opioid analgesics and sleep medications to effectively alleviate RLS symptoms.

What is the first line drug for restless leg syndrome?

Pregabalin, gabapentin, and gabapentin enacarbil, known as gabapentinoids, are often recommended as the first treatment option for chronic persistent restless leg syndrome (RLS) in many patients, according to research and medical experts.

What drugs worsen restless leg syndrome?

Various types of medication can exacerbate Restless Leg Syndrome (RLS). Specifically, anti-nausea drugs and sedative antihistamines like Benadryl can obstruct dopamine receptors in the brain, resulting in RLS symptoms. Furthermore, antidepressants that raise serotonin levels and antipsychotic drugs can also worsen the condition.

What vitamin is lacking with restless leg syndrome?

Considering these dopaminergic effects of vitamin D, our findings support the hypothesis that decreased vitamin D levels may lead to RLS symptoms.Apr 15, 2018

Does magnesium help restless legs?

There is anecdotal evidence that magnesium supplementation can help alleviate symptoms of restless legs syndrome (RLS) or period limb movement disorder (PLMD), as well as leg cramps, which is why it is often recommended for these conditions.

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